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»Primobolan by Promatrix 60 tablets

Promatrix Primobolan by Promatrix 60 tablets

Category: Condition Specific > Estrogen Inhibitors

Primobolan by Promatrix 60 tablets picture  Name: Primobolan by Promatrix 60 tablets

  Manufacturer: Promatrix

  Primobolan by Promatrix 60 tablets Description:


"Understanding Primobolan"


At first glance, the term Steroidal Aromatase Inhibitor sounds like a complex trio of words describing some powerful pharmaceutical agent or enzymatic process. In reality, it merely represents a group of hormonal related compounds that inhibits the enzyme in the human body responsible for the conversion of male hormones into female hormones. More specifically, it inhibits what’s called the aromatase enzyme, which converts androgens into estrogens. The normal metabolism of male androgens includes two main byproducts, female estrogens and male dihydrotestosterone (DHT).

If androgen metabolism is functioning normally, why would we want to inhibit the enzyme responsible for this function? The reason is that, under certain circumstances the body can produce too much estrogen or DHT, which can lead to a number of negative side effects. These side effects include decreased natural testosterone production, reduced sperm count, loss of muscle mass, and decreased strength.

Unique Functions


Steroidal aromatase inhibitors are compounds that decrease estrogen and DHT while at the same time producing a signal that stimulates natural androgen production. That’s right, they increase (natural) total and free testosterone concentrations by decreasing estrogen and DHT. Keep in mind that, not all steroidal aromatase inhibitors decrease DHT, but they all attempt to decrease total circulating estrogen levels.

Primobolan® does not need to directly convert into another hormone in order to be active. It is active in its initial state. It simply stimulates the body to produce more total and active testosterone. It does this by promoting luteinizing hormone (LH) and decreasing (SHBG) in order to increase natural production of testosterone while simultaneously increasing free or active testosterone. Keep in mind that other pro steroids only convert into a form of testosterone, which can shut down natural testosterone production and they do not increase both natural total and free testosterone levels. Now while Primobolan’s® dual effects are super charging your natural testosterone production, it is also decreasing female estrogen and androgenic DHT levels. That’s why Primobolan® is a must for those on andro or steroids.

Quest For The Best Chemical Variation Of Steroidal Aromatase Inhibitors.


There are several different chemical variations of steroidal aromatase inhibitors. Some of these androstene related compounds are patented by pharmaceutical companies and more recently by supplement companies. The most familiar pharmaceutical aromatase inhibitor has been shown to increase androgen levels in males.

Sounds great, right, well that’s what a supplement company thought when it planned to release this compound until it found that was patented by pharmaceutical giant Schering and then decided to drop it. The only other known aromatase inhibitor currently on the dietary supplement market is 5a-androstanedione. Now while this compound can inhibit estrogen biosynthesis it does not decrease DHT in fact, it has a weak conversion into DHT and it does not support natural testosterone production. Therefore this leaves Primobolan in a class of its own.

Benefits of Sports Nutrition Enthusiasts


The Sports Nutrition market should benefit the most from this type of compound. Serious and weekend athletes could receive increased muscle mass, recovery, strength and decreased body fat. Natural increases in total and free testosterone concentrations while simultaneously decreasing estrogen and DHT make this the single most important ergogenic compound in an athlete’s arsenal. The weekend athlete can effectively utilize these compounds in conjunction with creatine and protein in order to improve their physiques and or performance. The serious athlete may do the same or use these compounds in conjunction with other performance enhancing compounds. The serious athlete could also use some of these compounds to jump start natural androgen production after a cycle of anabolic steroids. Anabolic steroids tend to shut down natural androgen production and increase estrogen levels, which can cause an androgen deficiency. Steroidal aromatase inhibitors could be used to counter these negative side effects. Bodybuilders use drugs like Clomiphene citrate (Clomid®) in order block estrogen absorption and increase natural androgen production, but this is a powerful prescription pharmaceutical with its own set of side effects.

So where can you find some of these legal compounds that lower both estrogen and DHT while increasing natural androgen production? The compound is currently referred to as Primobolan®. It is an analog or derivative of a naturally occurring compound. It exerts all of the previously mentioned positive benefits associated with steroidal aromatase inhibitors and provides a mild anabolic effect without leaving banned metabolites in the system!

DESCRIPTION

Primobolan® oral tablets contain 100 mg of the chemically described as 4-Androsten-4-ol -3beta ,17beta-dione Acetate an irreversible, steroidal aromatase inhibitor.

 

Chemical Structure

Its molecular formula is C21 H28-04

The active ingredient is a white crystalline powder with a molecular weight of 344.4

 

Each Tablet contains the following:

Inactive ingredients: Magnesium Carbonate, Microcrystalline Cellulose, Pregelatinized Starch, Stearic Acid, Magnesium Stearate, and Croscramellose Sodium.

CLINICAL PHARMACOLOGY

The chemical term 4-Androstenoldione Acetate refers to the isomer:  4-Androsten-4-ol-3beta,17beta-dione Acetate.  4-Androstenoldione Acetate is the acetate ester derivative of 4-Hydroxy-4-Androstenedione, which is an analog or derivative of the naturally occurring precursor hormone 4-Androstenedione. 1 This compound concerns the isomer form of 4Androsten-4-ol-3beta,17beta-dione Acetate.

4-Androstenoldione Acetate is a steroidal aromatase inhibitor that inhibits estrogen biosynthesis, increases natural production of total and free testosterone, and may inhibit DHT formation. It does this by inhibiting the Cytochrone P-450 enzyme, which converts testosterone to estrogen. Once estrogen levels fall a signal is sent to the hypothalamic pituitary axis to produce (LH) luteinizing hormone and decrease (SHBG) steroid hormone binding globulin. 2 ,3  LH then stimulates the testes to increase total testosterone production, in which a large portion is free or active testosterone due to the decrease in SHBG. This increased amount of testosterone is then metabolized with less estrogen and DHT conversion.4

 

Metabolic Actions

Compounds in this class also may cause retention of nitrogen, sodium, potassium, and phosphorous, and decreased urinary excretion of calcium. Androgens have been reported to increase protein anabolism and decrease protein catabolism. Nitrogen balance is improved only when there is sufficient intake of calories and protein. Androgens have been reported to stimulate production of red blood cells by enhancing production of erythropoietic stimulation factor.

 

Pharmacokinetics

The compound is mainly eliminated by metabolism, renal excretion of metabolites accounting for 95% of dose. The excretory balance of 14C-compounds in urine and feces totals up to 98.9+/-0.8% of the i.v. dose after 168 h. The 14C-compounds in plasma and urine were separated by HPLC, and three major metabolites were submitted to structural analysis by MS, NMR and UV spectroscopy. One of the metabolites is the direct 4-O-glucuronide of formestane. The other two represent 3-O-sulfates of the exocons 3beta,4beta-dihydroxy-5alpha-androstane-17-one and 3alpha,4beta-dihydroxy-5alpha-androstane-17-one, their ratio being 7:3. These exocons are formed by stereoselective 3-keto reduction, accompanied by reduction of the 4,5-enol function. The exocons do not inhibit human placental aromatase activity in vitro. 5

 

The half-life orally was approximately 3 h, whereas the apparent half-life of injected drug was between 5 and 10 days after a more rapid clearance during the first 4 days after injection. The formulated material achieved a significantly higher mean peak concentration (88% greater than that obtained using the unformulated powder) and a higher mean AUC (not significant). The median time to peak was 1.5 h for both preparations and the elimination rate constants were similar (0.31 for micronized 4-OHA and 0.36 h-1 for formulated 4-OHA). Significant biological activity was demonstrated with the formulated material in its suppression of plasma oestradiol levels. 6  

 

Efficacy Studies

Subcutaneous treatment of immature male rats with an estrogen precursor, 19-hydroxy-testosterone (19-OHT), at a daily dose of 1 mg/animal for 14 days leads to a significant decrease in the weight of testis, ventral prostate and seminal vesicle. The peripheral levels of LH are lowered. Testicular histology indicates that the effects of 19-OHT are very similar to the known of effect induced by estradiol-17 beta. 19OHT induces a marked impairment of spermato and spermiogenesis. The maturation division is completely inhibited. The effect of 19-OHT on spermatogenesis is partially reversed by concomitant administration of an aromatase inhibitor (4-acetoxy-4-androstene-3.17-dione, (4-AA] at a dose of 1 mg/animal/day s.c. Meiotic activity is restored, and the weights of genital organs and the serum LH values increase. 4-AA alone has no appreciable effect on the parameters examined in this study. The present results suggest that specific inhibitors of estrogen biosynthesis might not only be useful to investigate the patho-physiological role of estrogens on spermatogenesis. 7

 

Clinical Studies

Another interesting note is the ability of 4-Androsten-4-ol-3, 17-dione acetate to directly stimulate testosterone whether in the presence of LH or not. Researchers examined the effects of placebo, luteinizing hormone (LH), 4-acetoxy-4-androstenedione, and luteinizing hormone (LH) plus 4-acetoxy-4-androstenedione on rat follicles in vitro.  In regards to testosterone they found that within the first 8 hours 4-acetoxy-4-androstenedione had the ability to directly stimulate testosterone alone and greatly stimulate testosterone in combination with luteinizing hormone (LH).  Interestingly enough within the next 16 hours they discovered 4-acetoxy-4-androstenedione alone was stimulating testosterone 3 times as much as luteinizing hormone (LH) while the combination also continued to stimulate testosterone. 8  (See Figure 1)

Figure 1*

FIG.1 Secretion of testosterone by preovulatory follicles isolated from PMSG-primed rats (2-3 follicles/dish, n = 6, mean ± SE/M) cultured for 24 h in the presence or absence of LH (5 mg/ml) and/or 4-acetoxy-A (5 mg/ml)

 

Estrogen inhibition was significant with 4-Androsten-4-ol-3, 17-dione acetate alone producing the greatest inhibition at both 8 and 24 hour intervals.8 (See Figure 2)
Figure 2*

FIG.2 Secretion of estradiol-17b by preovulatory follicles isolated from PMSG-primed rats (2-3 follicles/dish, n = 12, mean ± SE/M) cultured for 24 h in the presence or absence of LH (5 mg/ml) and/or 4-acetoxy-A (5 mg/ml).

INDICATIONS AND USAGE

Primobolan Acetate [4-Androsten-4-ol-3beta,17beta-dione Acetate for oral ingestion] is indicated for the long-term promotion of testosterone and regulation of estrogen in humans.

 

DOSAGE AND ADMINISTRATION

As a dietary supplement, take 1 to 2 tablets 3 times daily. Do not exceed recommended dose. 9The recommended daily dose in adults is 1-5 mg/kg body weight per day. The usual effective dose is 1-2 mg/kg/day but higher doses may be required, and the dose should be individualized. Response is not often immediate, and a minimum trial of three to six months should be given.

 

CONTRAINDICATIONS

Not to be used with any other medications especially oral hypoglycemic agents ie. Glyburide. 10

 

WARNINGS

Primobolan Acetate™ should not be used by children, during pregnancy, or by anyone contemplating pregnancy.

 

PRECAUTIONS

Do not use with any type of medication and use by individuals with any pre-existing medical condition is not recommended.

   

ADVERSE REACTIONS

With regard to toxicity, one patient developed a transient skin rash and another patient some facial swelling. A further patient developed a transient leucopaenia and treatment was therefore discontinued. Twenty-seven of the 30 evaluable patients (90%) experienced no side effects. These results indicate that oral administration is acceptable. 11
 

OVERDOSAGE

The recommended dosage of Primobolan Acetate™ should not be exceeded. Acute overdosage could lead to headache, nausea, vomiting, and/or hypoglycemia.

 

HOW SUPPLIED

Primobolan Acetate is supplied in HDPE bottles of 60 white  tablets imprinted with  on one side.

STABILITY AND STORAGE

Primobolan Acetate™ must be stored at room temperature. Do not expose the Primobolan Acetate to temperatures above 25°C (77°F).

 

 

References:
  1. National Library of Medicine - Medical Subject Headings 2001 MeSH MeSH Supplementary Concept Data; Biol Reprod 18:365; 1978; Endocrinology 106(1):19;1980; J Endocrinol Invest 1979;2(4):445

  2. Dowsett M, et al. Cancer Chemother Pharmacol 1990;27(1):67-71

  3. Brodie AM, et al.Steroids. 1981 Dec;38(6):693-702.

  4. Motta M, et al. J Steroid Biochem. 1986 Oct;25(4):593-600.

  5. Lonning PE, et al. J Steroid Biochem Mol Biol 2001 Apr;77(1):39-47

  6. Dowsett M, et al.Cancer Res.; VOL 49 ISS Mar 1989, P1306-1312, (REF25)

  7. Lescherber G, et al. 1989 Nov-Dec;21(6):529-34.

  8. Evans G, et al. Biol Reprod.1981 Sep;25(2):290-4.

  9. Dowsett M, et al Cancer Res 1987 Apr 1;47(7):1957-61

  10. Brankin E ; Br. Med. J.; VOL 314 ISS Mar 22 1997, P869, (REF) [IPA]

  11. Cunningham D, et al. Cancer Chemother Pharmacol 1987;20(3):253-5


Q: What is Primobolan Acetate?

 

A:To begin with, Primobolan Acetate is not a regular (andro) pro-hormone. It is the incorporation and application of today's latest science and technology, into the creation of a unique pharmaceutical grade product. Technically, it is a Steroidal Aromatase Inhibitor (4-Androsten-4-ol-3beta,17beta-dione Acetate) with a strong affinity for stimulating natural testosterone production.


Q:What makes Primobolan Acetate Different?

 

A:Here is the evolution of a compound never introduced before. Inhibits estrogen while simultaneously stimulating free and total testosterone while not relying on any conversion in the liver while enhancing pro-hormone effectiveness, while dealing with steroid side effects!!! Take a deep breath and enjoy.


Q:Why didn’t you combine Primobolan Acetate with other compounds?

 

A: Primobolan Acetate is so powerful that it does not require any other compound to make it more effective.


Q:What are the substances made of?

 

A:Primobolan Acetate ™ is made from a legally permitted compound, actually it is derived from the naturally occurring prohormone 4-androstene-3,17-dione.


Q:Which are the physiological principles that the compound is based on?

 

A:The philosophy behind Primobolan Acetate is based on various physiological factors and principles. The primary concern is to maintain a high anabolic environment within your system. In order to achieve this, only a sophisticated mechanism such as the Total Hormonal Manipulationcould succeed. It is a unique synergistic method of affecting all the endocrine modulators:

  • Influence the production of Free Testosterone at the highest level

  • Maintains high Total Testosterone levels, which is very important

  • Retains the lowest levels of cortisol-estrogens

 


Q:How does it work?

 

A:It simply stimulates the body to produce more total and active testosterone. It does this by inhibiting estrogen biosynthesis, which promotes luteinizing hormone (LH) and decreases (SHBG) in order to increase natural production of testosterone while simultaneously increasing free or active testosterone. So in other words it drops your estrogen levels and stimulates your test levels.


Q:Why is your product named Primobolan Acetate?

 

A:There is a sound reason behind this popular name. There you have it. Primobolan Acetate!!!!


Q: Why is Primobolan Acetate not time released?


A: It is scientifically proven that, long lasting pro-hormone release, has better effectiveness.  But the major side effect of it is that, similar to synthetics, such as steroids, there is a significant chance that your own production of testosterone may shut down. That’s the real beauty of our Primobolan Acetate; it does not continuously suppress your own production of testosterone, like the synthetics and time-released pro-hormones.  More so, since Primobolan Acetate acts by a different mechanism of action than most steroids it was concluded that time releasing would not increase activity but would only increase price. We then decided not to add an ineffective delivery system that other companies would use as a marketing advantage.


Q: Why does the Primobolan Acetate formulation not follow the cyclodextrin model?

 

A: Hydroxy Propyl Beta Cyclodextrin molecules are utilized to achieve greater oral bioavailability via buccal or sublingual administration. Primobolan Acetate has sufficient documentation on its oral bioavailability. (250mg to 500mg oral ingestion produces a significant effect) Since this compound has adequate oral bioavailability there is no need to use a chemical drug carrier.


Q: What are the Sophisticated actions?

 

A: Primobolan Acetate does not directly convert into another hormone in order to be active.  It is active in its initial state. It simply stimulates the body to produce more total and active testosterone. It does this by promoting luteinizing hormone (LH) and decreasing (SHBG) in order to increase natural production of testosterone while simultaneously increasing free or active testosterone.  Keep in mind that other pro steroids only increase or convert into a form of testosterone, which can shut down natural testosterone production and they do not increase both natural total and free testosterone levels. 

Now while Primobolan Acetate is super charging your natural testosterone production it is also decreasing female estrogen and androgenic DHT.  Estrogen and DHT are byproducts of testosterone, which can result in negative side effects such as gynocomastia and androgen related conditions.

Other pro steroids convert into different hormones, which can also shut down natural testosterone production and cause estrogen and DHT related side effects. Primobolan Acetate does the exact opposite.  It stimulates (natural) total and free testosterone function while decreasing estrogen and DHT.


Q: When Should I take Primobolan Acetate?


A: For maximum results take 1 to 2 tablets 3 times daily.  Take one tablet upon awakening then another at 45- 60 minutes before workout on your workout days and then one with dinner. On your non-workout days take one tablet upon awakening and one in the evening.


Q:How many bottles of Primobolan Acetate do I need in order to meet physiological effects?


A: Primobolan Acetate comes in one size (60 tablets).


Q: Should I cycle Primobolan Acetate or use it continuously all year long?

 

A:A: One of the unique features of this product is that you can use Primobolan Acetate continuously (24 weeks on 4 weeks off).


Q:I've been using Primobolan Acetate for six weeks now, what instructions should I follow, in order to help my body maintain its anabolic state?


A:
Well, if you started with 1 tablet 3 times daily then its time to increase your dosage to 2 tablets 3 times daily. Then maintain this dosage in order to receive continual gains.


Q: Will I decrease the effectiveness of Primobolan Acetate if I do not take it on an empty stomach?


A: Not at all. You will experience similar results either way. We suggest that you take it with a light meal. In the case of a heavy meal wait at least 2 hours before administration. You may take Primobolan Acetate with or without food. If you forget to take Primobolan Acetate, do not take an extra tablet. Just take the next tablet as usual. Primobolan Acetate will not work faster or better if taken all at once.


Q: I've had amazing gains with Primobolan Acetate. Will I lose everything if I stop using It?


A: Definitely not! Primobolan Acetate does not act as a water retention product. Keep in mind that, the foundation of any solid achievement is, dedication in your workouts, a healthy nutrition plan including plenty of protein, and lots of sleep. Following the fundamental training guidelines, you should be capable of maintaining most of your gains. Our studies indicate that Primobolan power stays, up to 4 weeks after use.


Q: Gym rumours state that letting it dissolve under my tongue (taking it sublingually),  provides a  better absorption?

 

A: Numerous athletes claim that any tablet has better absorption if you do so. If you can bare the bitter taste, there will not be any harm to take it sublingually.


Q:Can I Stack Primobolan Acetate with(andro) pro-hormone OR (AAS) Anabolic Steroid Hormone products?


A:
Yes you can stack all the above with Primobolan Acetate. We have researched several combinations that proved to be effective. Simply choose what prohormone, prosteroid, or anabolic steroid you wish to use and follow the normal steroid cycle pattern ie. 8 weeks on 4 weeks off while continually taking Primobolan in order to control estrogen and maintain the natural testosterone production of 20 year old male. So now instead of having raised estrogen levels and a cessation of natural testosterone production you have just the opposite resulting in much greater lean and permanent gains due to the dual action of the steroids and the surge in natural testosterone production.


Q: In order to lose my extra fat and gain pure muscle; what should I use Primobolan Acetate with?


A: By stacking Primobolan Acetate with FIREDRINE and THYROLAN you will melt fat like you never thought possible. They are the ultimate fat burning, energy boosting stacks in the industry. By stacking these with the powerful muscle building effects of Primobolan Acetate, you will have, in your possession, the most effective stack on the market to date.


Q: What other supplements should I take with Primobolan Acetate?


A: Firstly, no matter what degree of results you wish to achieve, you need to continuously consume large amounts of whey protein (we highly recommend ProWhey  from MVP Labs). Secondly, Absolute Powerfrom MVP Labs will enhance your explosiveness and strength by working in a completely different manner than Primobolan Acetate. Thirdly, don’t forget a strong vitamin & mineral formula that is high in antioxidants. Finally, get plenty of water and rest. Providing your body with Primobolan Acetate, protein, creatine, multivitamins, water and rest, will contribute to “Perfecting Your Human Performance”. 

And do not forget Primo is perfect for stacking with other Pro-steroids or hormones.  Primobolan can greatly enhance the effects of any pro-steroidal compound.


Q: Are there any side effects?

 

A: If you follow the directions suggested on the Personalized Dosing Page, there will be no danger to your health. Aside from pure muscle gains, strength and endurance, no other side effects have been reported. In several cases, Primobolan Acetate has also contributed to a healthier sex drive. 

↓DHT (Site specific DHT inhibition)


Q:Is Primobolan Acetate good for women?

 

A:We do not recommend Primobolan Acetate for women. This formula is just too effective in elevating testosterone levels to be healthy for any woman. High levels of testosterone in a woman, can deepen her voice, elevate the growth of facial hair, and disturb her menstrual cycles and more.


Q: I am 15 years old and I would like to start using Primobolan Acetate! What dosages would you recommend for a teenager like me?

 

A: If you are under the age of 18 years old, the appropriate dosage is ZERO tablets per day. IF YOU ARE UNDER 18 YEARS OLD, WE DO NOT RECOMMEND PRIMOBOLAN ACETATE. As a teenager, your body is already overloaded with testosterone & other hormones anyway. The last thing you need is a hormone elevating product.


Q: I'm a 230 pound bodybuilder and I was wondering if it's unsafe to consume 8-10 Primobolan Acetate tablets per day?

 

A: It depends on your body's level on tolerance. By now, only you would know this level. Please remember that when it comes to consuming extremely potent products like Primobolan Acetate, some individuals are much more sensitive than others. Note that, several of the top bodybuilders have been administering 8-10 tablets per day without any negative side effects.


Q:I am an athlete that has to go through random drug testing. Could Primobolan Acetate make me test positive for banned substances?

 

A: If you are an athlete competing in a league or an association that has the traditional list of banned substances, and are subject to random testing, you need to be aware of several facts. Primobolan Acetate does not convert into any banned substance or metabolite.  Now keep in mind that if Primobolan Acetate raises your natural testosterone production beyond the allowed amount then you will test positive. If on the other hand, you are subject to specific event or competition drug testing, you would need to stop administering Primobolan Acetate at least 2-4 weeks prior to the event.




  Primobolan by Promatrix 60 tablets Price: $50.95



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